Liver-specific fgfr4 knockdown in mice on an hfd increases bile acid synthesis and improves hepatic steatosis

HIGHLIGHTS

• who: Francois Moreau from the the Broad Institute University of KY, USA have published the paper: Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis, in the Journal: (JOURNAL)
• what: The authors have investigated the liver-specific role of FGFR4 on hepatic steatosis, lipid, and glucose metabolism. The authors show that a liver FGFR4 silencing increases Cyp7a1 expression and elevates hepatic bile acids. The authors show that FGFR4 KD in primary hepatocytes decreases ERK phosphorylation, which should ameliorate this risk.
• how: The quantitative PCR (qPCR . . .
  

   

  

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