Liver x receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model

HIGHLIGHTS

• who: François Briand from the Department du Québec, Les Ulis, France have published the paper: Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model, in the Journal: (JOURNAL) of 23/Oct/2009
• what: To better perform preclinical profiling of compounds affecting RCT (e_g, LXR agonists), the authors aimed to develop a nutritional model with a similar lipoprotein metabolism compared with humans.

SUMMARY

In mice, activation of LXR has been shown to promote in_vivo reverse cholesterol transport (RCT), a process by which cholesterol . . .

 



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