Lkb1/ampk syndrome models

HIGHLIGHTS

• who: HRAS germline mutations impair and colleagues from the France Bordeaux University have published the paper: LKB1/AMPK syndrome models, in the Journal: (JOURNAL)
• what: The authors explored the bioenergetics of the heart and skeletal muscle in different cell and animal models of CS and discovered alteration in the molecular control of mitochondrial proteostasis. The authors discovered a reduction of LKB1 protein content in CS mouse hearts and skin fibroblasts from patients with CS; this is in agreement with results from a previously published work that showed that genetic deletion of LKB1 in the heart . . .
  

   

  

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