Lkb1 suppresses amino acid-driven gluconeogenesis in the liver

HIGHLIGHTS

• who: Pierre-Alexandre Just from the Institut Paris Diderot, Sorbonne Paris Cité, Paris, France have published the paper: Lkb1 suppresses amino acid-driven gluconeogenesis in the liver, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: Using mice with a hepatocyte-specific Lkb1 deficiency, the authors characterize a new role of Lkb1 in the control of hepatic amino_acid catabolism, identifying Lkb1 as a suppressor of gluconeogenesis from amino_acids. The authors show that, in addition to its known effects on hepatic gluconeogenesis, the loss of hepatic Lkb1 increases the uptake and catabolism of amino_acids in the liver . . .
  

   

  

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