Lncrna anril mediates endothelial dysfunction through bdnf downregulation in chronic kidney disease

HIGHLIGHTS

• who: Hong Su from the In conclusion, our study found that the circulating ANRIL level was correlated with vascular endothelial dysfunction in patients with CKDThen our study provides evidence to demonstrate that ANRIL mediated endothelial dysfunction through BDNF downregulation. Our results indicate that ANRIL directly binds to EZH2, and mediates BDNF promoter methylation through recruitment of , to the BDNF promoter region, eventually resulting in endothelial dysfunction (Fig., ). These findings provided evidence to suggest that ANRIL was involved in the development of cardiovascular complications in CKD. and the exact molecular mechanisms need further exploration. MATERIAL AND METHODS Patients . . .
  

   

  

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