Lncrna-hotair activates autophagy and promotes the imatinib resistance of gastrointestinal stromal tumor cells through a mechanism involving the mir-130a/atg2b pathway

HIGHLIGHTS

• who: Jinyan Zhang from the suppress autophagyAdditionally, we found that the upregulation of HOTAIR did not increase drug resistance after knockdown of ATG B. Our findings suggested that HOTAIR regulates chemoresistance in GIST cells through a mechanism involving the miR-130a/ATG B axis. In summary, we discovered a new function of HOTAIR in regulating autophagy and chemoresistance in GIST cells by targeting miR-130a directly. Thus, HOTAIR might be a new molecular marker in patients with GIST with imatinib resistance. However, miR-130a is not the only target of HOTAIR regulation have published the research: LncRNA . . .
  

   

  

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