Local and global effects of sedation in resting-state fmri: a randomized, placebo-controlled comparison between etifoxine and alprazolam

HIGHLIGHTS

• What: The authors used rs-fMRI and behavioural assessments to compare neural correlates and side effects elicited by a TSPO ligand (etifoxine) and a benzodiazepine (alprazolam) in a threearmed, double-blind, placebo-controlled repeated-measures study. The authors focused on the very-lowfrequency range 0.01-0.05 Hz, which has been reported to increase during midazolam sedation and anaesthesia . To relate these regions altered by treatment with alprazolam to commonly observed resting-state networks, the authors provide an overlay of all modulations with the 7 resting-state networks defined by Yeo et_al in Figs S8, S9 . . .
  

   

  

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