HIGHLIGHTS
SUMMARY
The spreading of heterochromatin, and thus gene silencing distal to the nucleation site (nucleation-distal silencing) occurs in at least two very different chromatin contexts: 1. Beyond the differences between active and inactive chromatin, it remains unclear whether distinct Overlapping and unique genetic requirements for heterochromatin spreading in different chromatin contexts nucleation element classes require different regulators to enact efficient spreading outward from those sites. Design of heterochromatin spreading sensors that assess four chromatin contexts To explore whether different genetic contexts utilize general or specific sets of regulators for nucleation-distal gene silencing, the . . .
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