HIGHLIGHTS
- who: Press and collaborators from the Institut Masaryk University have published the paper: Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication, in the Journal: (JOURNAL)
- what: The authors propose that, in the face of genotoxic replication stress, SUMO/SLD-dependent chromatin interactions and proteolytic events are wired to promote local recombination by suppressing the Srs2 helicase, which normally prevents unscheduled recombination at undamaged replicating chromosomes. The authors propose that Esc2 SLDs act as a platform to recruit Slx5- Slx8 to its substrates at . . .
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