Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement

HIGHLIGHTS

• who: Viviana P. Ferreira from the DepartmentUniversity of Toledo, Toledo, OH, USA have published the research work: Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement, in the Journal: (JOURNAL)
• what: Properdin, the only positive regulatory protein of the complement system, and the focus of this review, extends the half-life of the nascent C3b,Bb convertase (5-10-fold) by forming the complex C3b,Bb,P (Fearon and Austen, 1975; Schreiber et_al, 1975), leading to accelerated and efficient amplification of C3b deposition on . . .
  

   

  

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