Local unfolding in a destabilized, pathogenic variant of superoxide dismutase 1 observed with h/d exchange and mass spectrometry*

HIGHLIGHTS

• who: Bryan Francis Shaw from the (UNIVERSITY) have published the paper: Local Unfolding in a Destabilized, Pathogenic Variant of Superoxide Dismutase 1 Observed with H/D Exchange and Mass Spectrometry*, in the Journal: (JOURNAL) of June/30,/2006
• what: The authors report here the results of studies using HX-MS to study the structure and dynamics of the pathogenic A4V variant of SOD1 in both the apoSOD1S-S and apoSOD12SH states.

SUMMARY

As is the case with proteins that cause other familial protein aggregation diseases, this increased aggregation propensity cannot be . . .

 



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