Locking the kink in the influenza hemagglutinin fusion domain structure*

HIGHLIGHTS

• who: Alex L. Lai from the Alex LLai and Lukas K. Tamm, From the Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia , We have previously identified Trp, as a critical residue that stabilizes the kink in the boomerang structure of the influenza fusion domain and found that cells expressing hemagglutinin with a Trp, to Ala mutation cannot fuse with red blood cells. However, mutating another aromatic residue, Phe9, on the other side of the kink did not have a significant effect on fusion or the ability of the mutant fusion peptide to bind . . .
  

   

  

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