Logic-gated antibody pairs that selectively act on cells co-expressing two antigens

HIGHLIGHTS

• who: Simone C. Oostindie from the Leiden University have published the Article: Logic-gated antibody pairs that selectively act on cells co-expressing two antigens, in the Journal: (JOURNAL) of 30/03/2021
• what: The approach the authors describe here solely decouples binding from functional activation to achieve selectivity and is therefore not dependent the environmental presence of secondary molecules such as enzymes or proteases.
• how: To assess whether cytotoxicity of the IgG1-Campath-RGE and IgG1-11B8-AGK combination is restricted to cells co-expressing and the authors analyzed the CDC activity . . .
  

   

  

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