Long-lived plasma cells and memory b cells produce pathogenic anti-gad65 autoantibodies in stiff person syndrome

HIGHLIGHTS

• who: Syndrome and colleagues from the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany, Centre of Chronic Immunodeficiency, University have published the paper: Long-Lived Plasma Cells and Memory B Cells Produce Pathogenic Anti-GAD65 Autoantibodies in Stiff Person Syndrome, in the Journal: (JOURNAL) of May/26,/2010
• how: The authors analyzed the enzyme-inhibiting activity of IgG isolated from both twins.

SUMMARY

Since plasma cells do not express the B cell surface marker CD20 they are not removed by treatment with monoclonal_antibodies like rituximab, which is . . .

 



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