HIGHLIGHTS
- who: Nicola Berretta and Nicola B. Mercuri from the Hokkaido University, Japan have published the article: Long-Term Depression of Striatal DA Release Induced by mGluRs via Sustained Hyperactivity of Local Cholinergic Interneurons, in the Journal: (JOURNAL)
- what: The authors provide evidence that the striatal DAergic transmission, measured with amperometric recordings of evoked DA release, is subject to a prolonged depression in its efficacy, in response to chemical stimulation of group I mGluRs by DHPG. The molecular and ionic mechanisms underlying the long-lasting hyperexcitability of striatal ChIs will be a subject of further investigation . . .
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