Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia

HIGHLIGHTS

• who: D Pal from the (UNIVERSITY) have published the research: Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia, in the Journal: (JOURNAL)
• what: The authors show that primary and patient-derived ALL cells can be successfully expanded ex vivo often over prolonged periods of time, without loss of leukaemic self-renewal potential and while maintaining the multitude of founder clones in these cultures. Through fate mapping the authors show that hundreds of founder clones establish the leukaemia in these cultures, continue to contribute to the in_vitro expanding . . .
  

   

  

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