Long-term inhibition of mutant lrrk2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects

HIGHLIGHTS

• who: Philip Wing-Lok Ho from the maintained with unrestricted access to food and water on a , h light-dark cycle, with lights on at , AM in the Laboratory Animal Unit, University of Hong Kong (HKU), with accreditation through the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC), under standard conditions (, h light/dark cycle)All experimental protocols were approved by the Committee on the Use of Live Animals in Teaching and Research (CULATR) of HKU. Generation and culture of mouse embryonic fibroblasts (MEFs) Littermate-matched WT and LRRK R G mutant mouse embryonic fibroblasts . . .
  

   

  

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