Long-term organoid culture of a small intestinal neuroendocrine tumor

HIGHLIGHTS

• who: Sabrina Du2019Agosto from the The Ohio State University, United States have published the research work: Long-term organoid culture of a small intestinal neuroendocrine tumor, in the Journal: (JOURNAL)
• what: The model faithfully recapitulates the major molecular features of the tissue (including the proliferation rate), could be propagated extensively, and was used to test the activity of targeted agents. In present study, the authors reported copy gain of chromosome 4 and in particular of KIT gene locus which was previously reported as altered in siNET . The authors focus on the analysis of transcription factors . . .
  

   

  

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