Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with osaka mutation

HIGHLIGHTS

• who: Marina Cu00e9lestine from the (UNIVERSITY) have published the Article: Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with Osaka mutation, in the Journal: (JOURNAL)
• what: We showed that a single inoculation of Au03b2osa induces a long-term cascade of events leading to increased Au03b2 aggregation and Au03b2 oligomers in the brain.
• how: The authors showed that intracerebral inoculation of Au03b2osa seeds in the hippocampus of a mouse model of amyloidosis worsens the clinical outcome associated with Au03b2 deposition 4 mpi.
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