HIGHLIGHTS
- who: Xiaoping Sun and collaborators from the Laboratory on Aging, NIH, Baltimore, Maryland, USA have published the paper: Longitudinal analysis reveals age-related changes in the T_cell receptor repertoire of human T_cell subsets, in the Journal: (JOURNAL)
- what: The authors conducted a longitudinal assessment of the TCRu03b1 and TCRu03b2 repertoires in naive and memory CD4+ and CD8+ T_cells from healthy adults. The authors show that T_cell subsets display distinct agerelated TCR repertoire changes and that the CD8+ TCR repertoire reduces with age more profoundly than the CD4+ TCR repertoire by an RNA-based UMI-corrected . . .
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