Losartan attenuates sex-dependent hypertension, neuroinflammation, and cognitive impairment in the aging male sprague–dawley rat

HIGHLIGHTS

• What: These studies were designed to investigate the hypothesis that BBB disruption and neuroinflammation in the PVN contributes to age-dependent hypertension in SD rats, age-dependent hypertension in SD rats is associated with cognitive impairment, and_(3) the use of antihypertensive therapeutics to lower blood pressure in aged SD rats with established hypertension improves cognitive function. Taken together, the authors propose the aging SD rat as a model of E Percent of time spent at novel object in hydrochlorothiazide treated rats before (PreTx) and after treatment (n=6/group).
• Who: Kayla M. Nist from . . .
  

   

  

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