Loss of bcl9/9l suppresses wnt driven tumourigenesis in models that recapitulate human cancer

HIGHLIGHTS

• who: David M. Gay from the Garscube Estate, Switchback Road, Glasgow , BD, UKUniversity of have published the research: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors report that deletion of Bcl9/9l sensitises the murine epithelium to perturbation of the Wnt pathway and impacts the Lgr5-ISC population. The authors show that BCL9/9l are required for the acute transformation of the intestine following homozygous deletion of Apc and for Wnt-driven transcriptional programmes associated with APC loss. Crucially . . .
  

   

  

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