HIGHLIGHTS
- who: Sarah Ouahoud from the Department of Gastroenterology and Hepatology, Leiden University Medical Center, P, , RC Leiden, The Netherlands have published the Article: Loss of bone morphogenetic protein signaling in fibroblasts results in CXCL12-driven serrated polyp development, in the Journal: (JOURNAL)
- what: The authors investigated how the inactivation of BMPR1A in different resident stromal subsets affects intestinal homeostasis and polyp formation. The authors show that loss of BMPR1A signaling in fibroblasts leads to polyp development through upregulation of CXCL12, driving epithelial_cell proliferation and serrated polyp formation. This study shows that BMP signaling specifically in . . .
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