HIGHLIGHTS
- who: CAPS and collaborators from the National of, United States have published the research work: Loss of CAPS2/Cadps2 leads to exocrine pancreatic cell injury and intracellular accumulation of secretory granules in mice, in the Journal: (JOURNAL)
- what: The authors report that CAPS2 deficiency in mice resulted in various pathomorphological alterations in the intracellular membrane structures including the rER, Golgi, and SGs responsible for exocrine function in pancreatic acinar cells, as well as exocrine pancreatic cell injury including progressive acinar cell atrophy, increased u03b1SMA-positive aPSCs leading to fibrosis, and inflammatory cell infiltration (Supplementary Figure . . .
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