Loss of gsα in the postnatal skeleton leads to low bone mass and a blunted response to anabolic parathyroid hormone therapy*

HIGHLIGHTS

• who: Partha Sinha from the Mice-Generation of Gs␣OsxKO mice has been described previously (34, )Postnatal deletion of Gs␣ was achieved by administering , ␮g/ml doxycycline in drinking water from conception until birth. Rosa, (R R, stock, ) (37) and mTmG reporter mice (38) were obtained from The Jackson Laboratory (Bar Harbor, ME). Because Gs␣OsxKO mice are of mixed genetic background, littermate controls (Gs␣(fl/fl) except where otherwise specified) were used for all experiments described. Generation of D/D mice has been described previously (39). Genotyping was performed on tail genomic DNA using protocols published . . .
  

   

  

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