Loss of hepatocyte cell division leads to liver inflammation and fibrosis

HIGHLIGHTS

  • who: Matthew R. Dewhurst and colleagues from the Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom have published the Article: Loss of hepatocyte cell division leads to liver inflammation and fibrosis, in the Journal: (JOURNAL)
  • what: The authors investigate whether blocking hepatocyte division using two different mouse models affects physiology as well as clinical liver manifestations like fibrosis and inflammation. The authors show that this could be caused by polyploidy as concurrent loss of Cdk2 reverses polyploidy . . .

     

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