HIGHLIGHTS
- who: Courtney W. Hanna et al. from the Epigenetics Programme, Babraham Institute, Cambridge, UK, Centre for Trophoblast Research, University of have published the research: Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation, in the Journal: (JOURNAL)
- what: Given the potential role of H3K4me3 in gene regulation, the authors focused first on gene promoters, considering active, weak and inactive promoters, as previously described by histone modifications and gene_expression in GV oocytes . The authors provide the first detailed characterization of epigenomic changes in Setd1b cKO oocytes.
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