Loss of mhc-i antigen presentation correlated with immune checkpoint blockade tolerance in mapk inhibitor-resistant melanoma

HIGHLIGHTS

• who: . and collaborators from the National Center for Nanoscience and Technology (CAS), China University of Macau, China have published the Article: Loss of MHC-I antigen presentation correlated with immune checkpoint blockade tolerance in MAPK inhibitor-resistant melanoma, in the Journal: (JOURNAL)
• what: This suggests that the down-expression of the MHC-I-mediated endogenous antigen presentation pathway is the main reason for the decline in T_cell infiltration during the drug resistance.
• how: Because the therapeutic Frontiers in Pharmacology frontiersin.org 10.3389/fphar.2022.928226 expression profiling data were obtained by aligning . . .
  

   

  

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