Loss of net as repressor leads to constitutive increased c-fos transcription in cervical cancer cells*

HIGHLIGHTS

• who: Jan van Riggelen from the pletely suppress c-fos in , cells (Fig B). Hence, we currently cannot answer the question, whether Net is acting as tumor suppressor, because its simple overexpression in malignant cells did not block cellular growth in nude mice (data not shown). However, transient delivery of siRNA against net resulted in increased c-fos transcription in asynchronized , hybrids, unequivocally demonstrating a causal relationship between Net and c-fos expression in non-tumorigenic cells (Fig. D). It will be worthwhile in future experiments whether a stably introduced Net siRNA transcription cassette leads to similar . . .
  

   

  

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