Loss of prm1 leads to defective chromatin protamination, impaired prm2 processing, reduced sperm motility and subfertility in male mice

HIGHLIGHTS

• who: KEY WORDS Protamine ratio and colleagues from the During spermatogenesis in the seminiferous epithelium of the testis, diploid spermatogonia differentiate into haploid spermatidsOne of the most remarkable changes during spermiogenesis is complete reorganization of chromatin compaction (Rathke et_al, ), whereby histones are almost completely substituted by protamines. These are highly basic, arginine-rich proteins (Balhorn, ) that, upon binding to DNA, hypercondense chromatin, leading to , Department of Developmental Pathology, Institute of Pathology, University Hospital Bonn, Bonn, Germany. Department of Urology, Pediatric Urology and Andrology, Section Molecular Andrology, Biomedical Research Center of the Justus-Liebig University, Giessen, Germany. Department . . .
  

   

  

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