Loss of pyruvate kinase m2 limits growth and triggers innate immune signaling in endothelial cells

HIGHLIGHTS

• who: Oliver A. Stone from the Max Planck Institute for Heart and Lung Research, Ludwigstrasse, Bad Nauheim, GermanyDuke University have published the Article: Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that loss of PKM2 in ECs results in TCA cycle dysfunction, cell cycle arrest and the induction of viral mimicry by endogenous retroviral transcripts. The authors provide evidence that impaired nucleotide synthesis in cells lacking PKM2 can be regulated at the transcriptional level by RELB-P53 . . .
  

   

  

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