Loss of the candidate tumor suppressor zeb1 (tcf8, zfhx1a) in sézary syndrome

HIGHLIGHTS

• who: Elisabetta Caprini from the (UNIVERSITY) have published the research: Loss of the candidate tumor suppressor ZEB1 (TCF8, ZFHX1A) in Sézary syndrome, in the Journal: (JOURNAL)
• what: The authors provide evidence that ZEB1 activity in Sézary cells influencing the reactive oxygen species production affects cell viability and apoptosis. The authors report ZEB1 as the target of a significant focal deletion with a correspondent transcript downregulation. The authors show, for the first time, that SS patients harbor not only ZEB1 somatic mutations, but also germline variations; the authors found that 8/ 11 allelic variants . . .
  

   

  

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