Loss of the collagen iv modifier prolyl 3-hydroxylase causes thin basement membrane nephropathy

HIGHLIGHTS

• who: Hande Aypek et al. from the Institut University Medical Center Hamburg-Eppendorf, Hamburg, Germany have published the research work: Loss of the collagen IV modifier prolyl 3-hydroxylase causes thin basement membrane nephropathy, in the Journal: (JOURNAL)
• what: The study shows that podocyte-specific P3h2-KO mice (referred to hereafter as P3h2u0394Pod or KO mice) mice initially have a TBMN phenotype that slowly progresses to a FSGS phenotype. The authors aimed to evaluate the effect of an absence of P3H2 on the 3Hyp of proline residues of collagen IV. To take into account the . . .
  

   

  

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