HIGHLIGHTS
- who: Maria T. Bengoechea-Alonso and colleagues from the melweis University, Hungary Hong Kong Baptist University, China have published the Article: Loss of the Fbw7 tumor suppressor rewires cholesterol metabolism in cancer cells leading to activation of the PI3K-AKT signalling axis, in the Journal: (JOURNAL)
- what: In the current manuscript the authors demonstrate that inactivation of Fbw7 in cancer cells results in the stabilization and activation of nuclear SREBP1a. The authors propose that the loss of Fbw7 promotes sustained lipid synthesis to support the rapid proliferation of cancer cells. The authors propose that this . . .
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