Loss of tip60 (kat5) abolishes h2az lysine 7 acetylation and causes p53, ink4a, and arf-independent cell cycle arrest

HIGHLIGHTS

  • who: Johannes Wichmann from the (UNIVERSITY) have published the research: Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest, in the Journal: (JOURNAL) of 28/04/2021
  • what: For the subsequent analysis, the authors focused on genes differentially Cell Death and Disease 13:627 expressed 3 days after induction of Tip60 deletion to avoid secondary effects of loss of TIP60, at which time a total of 6311 genes were differentially expressed . The authors induced TIP60 deletion in normal mouse cells, immortalized human cells, and human . . .

     

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