Loss of tmem106b exacerbates c9als/ftd dpr pathology by disrupting autophagosome maturation

HIGHLIGHTS

• who: Claudia S. Bauer from the United Kingdom McGill University Health Centre have published the paper: Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation, in the Journal: (JOURNAL)
• what: The authors show that restoration of autophagosome maturation rescues DPR protein accumulation. This study shows that reduction of TMEM106B expression impairs autophagy , suggesting the possibility that the disease modifying effect of Frontiers in Cellular Neuroscience frontiersin.org 10.3389/fncel.2022.1061559 Restoring Arl8b-mediated lysosomal trafficking rescues impaired autophagy in TMEM106B-depleted cells. Crucially the authors show that restoring autophagy, in . . .
  

   

  

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