Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures

HIGHLIGHTS

• who: Susanne Fleig from the Department University Hospital, Hannover, Germany have published the Article: Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 14/05/2020
• what: The authors show that conditional loss of Notch signaling by deletion of the canonical mediator Rbpj in blood vascularendothelial cells modifies arterial endothelial identity and shifts it to an HEV-like phenotype, which in turn is associated with the spontaneous formation of TLS in mouse kidney, liver, and lung.
• how: To investigate whether renal . . .
  

   

  

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