Low-intensity pulsed ultrasound promotes mesenchymal stem cell transplantation-based articular cartilage regeneration via inhibiting the tnf signaling pathway

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SUMMARY

    Human umbilical cord mesenchymal stem_cells (hUC-MSCs) have shown stronger proliferation and differentiation ability compared with human bone mesenchymal stem_cells (hBMSCs) and human adipose-derived mesenchymal stem_cells (hAD-MSCs). Through thermal and non-thermal mechanisms, ultrasound can produce various biological effects in_vitro and in_vivo, including mechanical effect, tissue temperature rise, acoustic cavitation, and acoustic streaming. Rat knee articular cartilage defect models were established to verify LIPUS- and hUCMSC-based cartilage regeneration in_vivo. Although the concept of "LIPUS-stimulated and hUCMSC-mediated cartilage regeneration" has been previously reported, this study validated in_vivo experiments in injured . . .

     

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