Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions

HIGHLIGHTS

  • who: Oliver Thompson from the Department University of London, London , RT, UK have published the Article: Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
  • how: When the authors applied paired MannWhitney testing with Bonferroni correction to compare the median mutation rates of each chromosome to the respective genome-wide rate under each growth condition none of the autosomes showed significant deviation from the genomewide rate. To look for epigenetic changes the authors used whole-genome bisulphite sequencing (WGBS) data obtained from . . .

     

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