Lowering bile acid pool size with a synthetic farnesoid x receptor (fxr) agonist induces obesity and diabetes through reduced energy expenditure*

HIGHLIGHTS

• who: Mitsuhiro Watanabe from the EXPERIMENTAL PROCEDURES Materials-CA was obtained from Sigma, was a generous gift of Mitsubishi Pharmaceuticals. Animal Studies-Animal experiments were approved by the institutional review board at Keio University. Male C BL/ J mice, , weeks of age, were obtained from Charles River Laboratories (l'Arbresle, France) and CLEA Japan, Inc. (Tokyo, Japan). All mice were maintained in a temperature-controlled (, °C) facility with a, h light/dark cycle and were given free access to food and water. The control diet and high fat diet were obtained from Research Diets, Inc. The control . . .
  

   

  

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