Lpm3770277, a potent novel cdk4/6 degrader, exerts antitumor effect against triple-negative breast cancer

HIGHLIGHTS

• who: CDK and collaborators from the Key Laboratory of Molecular and Evaluation (Yantai, School of Pharmacy, Ministry of Education, China, Luye, China, School of Pharmacy, Binzhou Medical, China have published the paper: LPM3770277, a Potent Novel CDK4/6 Degrader, Exerts Antitumor Effect Against Triple-Negative Breast Cancer, in the Journal: (JOURNAL)
• what: The authors designed a novel hydrophobic tagging compound LPM3770277 aiming to degrade CDK4/6 protein in TNBC. The primary findings of this study were that the authors developed and evaluated a novel CDK4/6 degrader, LPM3770277, based on hydrophobic tagging technology.
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