HIGHLIGHTS
- who: Xiaojuan Cheng and collaborators from the Department of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou, China have published the paper: LRRK2 Deficiency Aggravates Sleep Deprivation-Induced Cognitive Loss by Perturbing Synaptic Pruning in Mice, in the Journal: (JOURNAL)
- what: Our findings provide insights into the physiological role of LRRK2-mediated pathways in regulating microglial synaptic pruning with respect to modulating SD-related cognitive disorders.
- how: The results showed that after SD LRRK2-deficient mice displayed lengthened NREM and shortened REM and reported decreased dendritic . . .
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