Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

HIGHLIGHTS

• who: Barbara Spix from the Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany, have published the research: Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show here a link between an endolysosomal cation_channel, TRPML3, and the development of lung dysfunction and an | https://doi.org/10.1038/s41467-021-27860-x n.s. In sum, the authors show here that Trpml3-/- mice are highly vulnerable to emphysema and COPD development. The authors further deliver a molecular rationale for the observed lung . . .
  

   

  

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