Lysine nζ-decarboxylation switch and activation of the β-lactam sensor domain of blar1 protein of methicillin-resistant staphylococcus aureus*

HIGHLIGHTS

• who: Oleg Borbulevych from the Oleg Borbulevych, Malika Kumarasiri, Brian Wilson, Leticia ILlarrull1, Mijoon Lee, Dusan Hesek, Qicun Shi, Jeffrey Peng, Brian M. Baker, and Shahriar Mobashery, From the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana , The integral membrane protein Bla, of methicillin-resistant Staphylococcus aureus senses the presence of ␤-lactam antibiotics in the milieu and transduces the information to the cytoplasm, where the biochemical events that unleash induction of antibiotic resistance mechanisms take place. We report herein by two-dimensional and three-dimensional NMR experiments of the sensor domain of Bla . . .
  

   

  

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