Lytic reactivation of the kaposi’s sarcoma-associated herpesvirus (kshv) is accompanied by major nucleolar alterations

HIGHLIGHTS

• who: Nofar Atari and colleagues from the , have published the paper: Lytic Reactivation of the Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Is Accompanied by Major Nucleolar Alterations, in the Journal: Viruses 2022, 14, x FOR PEER REVIEW of 16/07/2022
• what: The authors provide evidence that pre-rRNA transcription proceeds and rRNA processing continues. The authors demonstrate small changes in rRNA modifications (pseudouridylation and 20 -O-methylation) upon lytic virus reactivation, likely affecting ribosome function during virus propagation. Using different approaches, the authors show rRNA levels do not change during the lytic cycle.
 



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