Mab21l1 promotes survival of lens epithelial_cells through control of

HIGHLIGHTS

• who: u03b1B-crystallin et al. from the College of Life Sciences, Hunan Normal University, Changsha, Hunan, China have published the research: MAB21L1 promotes survival of lens epithelial_cells through control of, in the Journal: (JOURNAL)
• what: The authors demonstrate that Mab21L1 promotes survival of lens epithelial cells. The authors demonstrate that u03b1B-crystallin prevents p53 phosphorylation at multiple sites through abrogating activation of the ATR and CHK1 kinases. The study demonstrates that u03b1B-crystallin can modulate p53 phosphorylation status at S-20 and S-37 to inhibit its activity.

SUMMARY

In lens . . .

 



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