Macrocylases as synthetic tools for ligand synthesis: enzymatic synthesis of cyclic peptides containing metal-binding amino acids

HIGHLIGHTS

• who: Amanda G. Jarvis and colleagues from the EaStCHEM School of, University of Edinburgh, Joseph Black Building have published the article: Macrocylases as synthetic tools for ligand synthesis: enzymatic synthesis of cyclic peptides containing metal-binding amino acids, in the Journal: (JOURNAL) of 02/Oct/2022

SUMMARY

One of the advantages of studying metallopeptides is that well-established routes to large libraries of peptide variants, including unnatural amino_acids, are available using solid-phase peptide synthesis (SPPS). Key challenges still arise in the synthesis peptides, including efficient access to enantiomerically pure amino_acids and cyclization . . .

 



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