HIGHLIGHTS
- who: Luca Peruzzotti-Jametti from the Department University of Cambridge, Cambridge, UK have published the article: Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation, in the Journal: (JOURNAL)
- what: The authors show transplanted somatic and directly induced ameliorate chronic CNS inflammation by reducing succinate levels the cerebrospinal fluid thereby decreasing mononuclear phagocyte (MP) infiltration and secondary CNS damage. Beyond the structural replacement of injured CNS cells, the work has shown that transplanted NSCs engage in complex stem_cell graft-to-host communication programs, overall leading to trophic support and modulation of adaptive . . .
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