HIGHLIGHTS
- who: Will Wood from the University of Bristol, Bristol , TD, UK have published the research work: Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly, in the Journal: (JOURNAL)
- what: This study shows that before phagocytosing an apoptotic corpse, macrophages are naive and incapable of sensing wound signals or microbes, but upon their first corpse engulfment they exhibit a calcium flash that triggers a JNK-mediated upregulation of the CED-1 homolog Draper, which appears to drive a mid- to long-term priming to enable responsiveness to wounds and infections .
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