Macrophage notch1 inhibits tak1 function and ripk3-mediated hepatocyte necroptosis through activation of β-catenin signaling in liver ischemia and reperfusion injury

HIGHLIGHTS

• who: Dongwei Xu from the Department of Liver Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China have published the article: Macrophage Notch1 inhibits TAK1 function and RIPK3-mediated hepatocyte necroptosis through activation of u03b2-catenin signaling in liver ischemia and reperfusion injury, in the Journal: (JOURNAL)
• what: This study investigated the molecular mechanisms of in modulating TAK1-mediated innate immune responses and RIPK3 functions in liver IRI. This study showed that CRISPR/ Cas9-mediated TRAF6 KO inhibited TNF-u03b1 release in u00adNotch1M-KO macrophages under LPS stimulation.
• how: The results . . .
  

   

  

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